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Fig. 3 Gas6-dependent AXL receptor activation enhances GnRH receptor signaling processes. A Proportion of phosphorylated ERK relative to total ERK (pERK/ERK) in αT3-1 and LβT2 cells under control conditions and after incubation with Gas6 (100 nM for 3 h); n = 3 for each condition. B Time course of Gas6-dependent changes (100 nM) in pERK/ERK in LβT2 cells (from left); effect of incubating LβT2 cells with GnRH (10 nM) and GnRH plus Gas6 (100 nM) for 5 min on pERK/ERK (at right); n = 3 for each condition. C Time course of Gas6-dependent (100 nM) changes on Egr-1 transcript abundance in αT3-1 and LβT2 cells; n = 3. D LHβ protein abundance in the culture media and lysates of LβT2 cells under control conditions and after 2 h incubations with Gas6 (100 nM) and GnRH (10 nM); n = 3. € LHβ protein abundance in LβT2 culture media under control conditions and after 2 h incubations with Gas6 (100 nM), GnRH (10 nM), the GnRH receptor antagonist <t>cetrorelix</t> (2 nM), the AXL receptor antagonist R428 (50 µM), and the MEK inhibitor U0126 (10 µM); n = 3 for each condition. n = number of independent experiments; numerical data presented as mean ± SEM; * P < 0.05
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cetrorelix acetate injection cetrotider  (Merck KGaA)
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Fig. 3 Gas6-dependent AXL receptor activation enhances GnRH receptor signaling processes. A Proportion of phosphorylated ERK relative to total ERK (pERK/ERK) in αT3-1 and LβT2 cells under control conditions and after incubation with Gas6 (100 nM for 3 h); n = 3 for each condition. B Time course of Gas6-dependent changes (100 nM) in pERK/ERK in LβT2 cells (from left); effect of incubating LβT2 cells with GnRH (10 nM) and GnRH plus Gas6 (100 nM) for 5 min on pERK/ERK (at right); n = 3 for each condition. C Time course of Gas6-dependent (100 nM) changes on Egr-1 transcript abundance in αT3-1 and LβT2 cells; n = 3. D LHβ protein abundance in the culture media and lysates of LβT2 cells under control conditions and after 2 h incubations with Gas6 (100 nM) and GnRH (10 nM); n = 3. € LHβ protein abundance in LβT2 culture media under control conditions and after 2 h incubations with Gas6 (100 nM), GnRH (10 nM), the GnRH receptor antagonist <t>cetrorelix</t> (2 nM), the AXL receptor antagonist R428 (50 µM), and the MEK inhibitor U0126 (10 µM); n = 3 for each condition. n = number of independent experiments; numerical data presented as mean ± SEM; * P < 0.05
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gnrh-a cetrorelix acetate for injection cetrotide  (Merck KGaA)
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Fig. 3 Gas6-dependent AXL receptor activation enhances GnRH receptor signaling processes. A Proportion of phosphorylated ERK relative to total ERK (pERK/ERK) in αT3-1 and LβT2 cells under control conditions and after incubation with Gas6 (100 nM for 3 h); n = 3 for each condition. B Time course of Gas6-dependent changes (100 nM) in pERK/ERK in LβT2 cells (from left); effect of incubating LβT2 cells with GnRH (10 nM) and GnRH plus Gas6 (100 nM) for 5 min on pERK/ERK (at right); n = 3 for each condition. C Time course of Gas6-dependent (100 nM) changes on Egr-1 transcript abundance in αT3-1 and LβT2 cells; n = 3. D LHβ protein abundance in the culture media and lysates of LβT2 cells under control conditions and after 2 h incubations with Gas6 (100 nM) and GnRH (10 nM); n = 3. € LHβ protein abundance in LβT2 culture media under control conditions and after 2 h incubations with Gas6 (100 nM), GnRH (10 nM), the GnRH receptor antagonist <t>cetrorelix</t> (2 nM), the AXL receptor antagonist R428 (50 µM), and the MEK inhibitor U0126 (10 µM); n = 3 for each condition. n = number of independent experiments; numerical data presented as mean ± SEM; * P < 0.05
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cetrorelix acetate  (ChemPep Inc)
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Fig. 3 Gas6-dependent AXL receptor activation enhances GnRH receptor signaling processes. A Proportion of phosphorylated ERK relative to total ERK (pERK/ERK) in αT3-1 and LβT2 cells under control conditions and after incubation with Gas6 (100 nM for 3 h); n = 3 for each condition. B Time course of Gas6-dependent changes (100 nM) in pERK/ERK in LβT2 cells (from left); effect of incubating LβT2 cells with GnRH (10 nM) and GnRH plus Gas6 (100 nM) for 5 min on pERK/ERK (at right); n = 3 for each condition. C Time course of Gas6-dependent (100 nM) changes on Egr-1 transcript abundance in αT3-1 and LβT2 cells; n = 3. D LHβ protein abundance in the culture media and lysates of LβT2 cells under control conditions and after 2 h incubations with Gas6 (100 nM) and GnRH (10 nM); n = 3. € LHβ protein abundance in LβT2 culture media under control conditions and after 2 h incubations with Gas6 (100 nM), GnRH (10 nM), the GnRH receptor antagonist <t>cetrorelix</t> (2 nM), the AXL receptor antagonist R428 (50 µM), and the MEK inhibitor U0126 (10 µM); n = 3 for each condition. n = number of independent experiments; numerical data presented as mean ± SEM; * P < 0.05
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cetrorelix acetate chempep  (ChemPep Inc)
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The weight (g) of the body, ovaries, uterus and liver of female control and experimental rats during one (I), two (II) and three month (III) lasting administration of placebo, dalarelin and <t> cetrorelix, </t> as well as after one (III+1), two (III+2) and four (III+4) weeks after discontinuation of a treatment.
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injection cetrorelix acetate 250 mcg  (Merck KGaA)
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The weight (g) of the body, ovaries, uterus and liver of female control and experimental rats during one (I), two (II) and three month (III) lasting administration of placebo, dalarelin and <t> cetrorelix, </t> as well as after one (III+1), two (III+2) and four (III+4) weeks after discontinuation of a treatment.
Injection Cetrorelix Acetate 250 Mcg, supplied by Merck KGaA, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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cetrorelix acetate daily injections  (Intas Pharmaceuticals)
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Schematic depiction of typical ovarian Stimulation protocols. In Group 1, GnRH Antagonist <t>(Cetrorelix</t> acetate 0.25 mg daily injections) was started from day 1 of stimulation concurrently with r-FSH ( A ); In Group 2, r-FSH was started on cycle day 1or 2 and flexible GnRH antagonist administration initiated from day 5 or 6 of stimulation ( B ).
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cetrorelix acetate  (Merck & Co)
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Schematic depiction of typical ovarian Stimulation protocols. In Group 1, GnRH Antagonist <t>(Cetrorelix</t> acetate 0.25 mg daily injections) was started from day 1 of stimulation concurrently with r-FSH ( A ); In Group 2, r-FSH was started on cycle day 1or 2 and flexible GnRH antagonist administration initiated from day 5 or 6 of stimulation ( B ).
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drugs cetrorelix acetate 20080312  (ChemPep Inc)
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Schematic depiction of typical ovarian Stimulation protocols. In Group 1, GnRH Antagonist <t>(Cetrorelix</t> acetate 0.25 mg daily injections) was started from day 1 of stimulation concurrently with r-FSH ( A ); In Group 2, r-FSH was started on cycle day 1or 2 and flexible GnRH antagonist administration initiated from day 5 or 6 of stimulation ( B ).
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cetrerelix (cetrorelix acetate; cetrotide)  (Merck KGaA)
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Schematic depiction of typical ovarian Stimulation protocols. In Group 1, GnRH Antagonist <t>(Cetrorelix</t> acetate 0.25 mg daily injections) was started from day 1 of stimulation concurrently with r-FSH ( A ); In Group 2, r-FSH was started on cycle day 1or 2 and flexible GnRH antagonist administration initiated from day 5 or 6 of stimulation ( B ).
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cetrorelix acetate  (Zoetis)
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Schematic depiction of typical ovarian Stimulation protocols. In Group 1, GnRH Antagonist <t>(Cetrorelix</t> acetate 0.25 mg daily injections) was started from day 1 of stimulation concurrently with r-FSH ( A ); In Group 2, r-FSH was started on cycle day 1or 2 and flexible GnRH antagonist administration initiated from day 5 or 6 of stimulation ( B ).
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Image Search Results


Fig. 3 Gas6-dependent AXL receptor activation enhances GnRH receptor signaling processes. A Proportion of phosphorylated ERK relative to total ERK (pERK/ERK) in αT3-1 and LβT2 cells under control conditions and after incubation with Gas6 (100 nM for 3 h); n = 3 for each condition. B Time course of Gas6-dependent changes (100 nM) in pERK/ERK in LβT2 cells (from left); effect of incubating LβT2 cells with GnRH (10 nM) and GnRH plus Gas6 (100 nM) for 5 min on pERK/ERK (at right); n = 3 for each condition. C Time course of Gas6-dependent (100 nM) changes on Egr-1 transcript abundance in αT3-1 and LβT2 cells; n = 3. D LHβ protein abundance in the culture media and lysates of LβT2 cells under control conditions and after 2 h incubations with Gas6 (100 nM) and GnRH (10 nM); n = 3. € LHβ protein abundance in LβT2 culture media under control conditions and after 2 h incubations with Gas6 (100 nM), GnRH (10 nM), the GnRH receptor antagonist cetrorelix (2 nM), the AXL receptor antagonist R428 (50 µM), and the MEK inhibitor U0126 (10 µM); n = 3 for each condition. n = number of independent experiments; numerical data presented as mean ± SEM; * P < 0.05

Journal: Cell communication and signaling : CCS

Article Title: AXL receptor tyrosine kinase modulates gonadotropin-releasing hormone receptor signaling.

doi: 10.1186/s12964-023-01313-y

Figure Lengend Snippet: Fig. 3 Gas6-dependent AXL receptor activation enhances GnRH receptor signaling processes. A Proportion of phosphorylated ERK relative to total ERK (pERK/ERK) in αT3-1 and LβT2 cells under control conditions and after incubation with Gas6 (100 nM for 3 h); n = 3 for each condition. B Time course of Gas6-dependent changes (100 nM) in pERK/ERK in LβT2 cells (from left); effect of incubating LβT2 cells with GnRH (10 nM) and GnRH plus Gas6 (100 nM) for 5 min on pERK/ERK (at right); n = 3 for each condition. C Time course of Gas6-dependent (100 nM) changes on Egr-1 transcript abundance in αT3-1 and LβT2 cells; n = 3. D LHβ protein abundance in the culture media and lysates of LβT2 cells under control conditions and after 2 h incubations with Gas6 (100 nM) and GnRH (10 nM); n = 3. € LHβ protein abundance in LβT2 culture media under control conditions and after 2 h incubations with Gas6 (100 nM), GnRH (10 nM), the GnRH receptor antagonist cetrorelix (2 nM), the AXL receptor antagonist R428 (50 µM), and the MEK inhibitor U0126 (10 µM); n = 3 for each condition. n = number of independent experiments; numerical data presented as mean ± SEM; * P < 0.05

Article Snippet: Test reagents used include: R428 (APExBio; Houston, TX), cetrorelix acetate (Tocris Bioscience; Minneapolis, MN), Gas6 (Novus Biologicals; Centennial, CO), GnRH (Sigma), and U0126EtOH (APExBio; Houston, TX).

Techniques: Activation Assay, Control, Incubation, Quantitative Proteomics

The weight (g) of the body, ovaries, uterus and liver of female control and experimental rats during one (I), two (II) and three month (III) lasting administration of placebo, dalarelin and cetrorelix, as well as after one (III+1), two (III+2) and four (III+4) weeks after discontinuation of a treatment.

Journal: Medical Science Monitor : International Medical Journal of Experimental and Clinical Research

Article Title: Morphological and enzymatic changes caused by a long-term treatment of female rats with a low dose of gonadoliberin agonist and antagonist

doi: 10.12659/MSM.883264

Figure Lengend Snippet: The weight (g) of the body, ovaries, uterus and liver of female control and experimental rats during one (I), two (II) and three month (III) lasting administration of placebo, dalarelin and cetrorelix, as well as after one (III+1), two (III+2) and four (III+4) weeks after discontinuation of a treatment.

Article Snippet: Dalarelin acetate (BAPEX, Ryga) – a gift from prof. F. Ryszka (Biochefa; Sosnowiec, Poland) – and cetrorelix acetate (ChemPep, Inc., USA) were used in the experiment.

Techniques: Control

Different effects of dalarelin and cetrorelix on morphological appearance of rat ovary (HE staining). Sections taken from control rats ( A ), and: after one month of dalarelin treatment ( B ), four weeks after a discontinuation of the three months lasting dalarelin treatment ( C ); after one ( D ) and three ( E ) months of cetrorelix administration, and four weeks after its discontinuation ( F ). Magnification: 40×.

Journal: Medical Science Monitor : International Medical Journal of Experimental and Clinical Research

Article Title: Morphological and enzymatic changes caused by a long-term treatment of female rats with a low dose of gonadoliberin agonist and antagonist

doi: 10.12659/MSM.883264

Figure Lengend Snippet: Different effects of dalarelin and cetrorelix on morphological appearance of rat ovary (HE staining). Sections taken from control rats ( A ), and: after one month of dalarelin treatment ( B ), four weeks after a discontinuation of the three months lasting dalarelin treatment ( C ); after one ( D ) and three ( E ) months of cetrorelix administration, and four weeks after its discontinuation ( F ). Magnification: 40×.

Article Snippet: Dalarelin acetate (BAPEX, Ryga) – a gift from prof. F. Ryszka (Biochefa; Sosnowiec, Poland) – and cetrorelix acetate (ChemPep, Inc., USA) were used in the experiment.

Techniques: Staining, Control

Effects of dalarelin and cetrorelix on morphological appearance of rat uterine endometrium. ( A–C ) HE staining; ( A ) control, 100×; ( B ) after two months of dalarelin injections (subnuclear and apical vacuolization in epithelial cells) and ( C ) four weeks after a discontinuation of the three months lasting dalarelin treatment, 200×; ( D–F ): VG staining, 100×; Collagen fibers are stained purple; ( D ) control; ( E ) two months of dalarelin treatment (signs of fibrosis), ( F ) two weeks after a discontinuation of the three months lasting dalarelin treatment; ( G–I ): HE staining; ( G, H ) After one and three months of cetrorelix administration (infiltration of granulocytes, apoptotic bodies), respectively; (I) two weeks after the cetrorelix treatment discontinuation; Magnification: ( G, I ) 100×, ( H ) 200×.

Journal: Medical Science Monitor : International Medical Journal of Experimental and Clinical Research

Article Title: Morphological and enzymatic changes caused by a long-term treatment of female rats with a low dose of gonadoliberin agonist and antagonist

doi: 10.12659/MSM.883264

Figure Lengend Snippet: Effects of dalarelin and cetrorelix on morphological appearance of rat uterine endometrium. ( A–C ) HE staining; ( A ) control, 100×; ( B ) after two months of dalarelin injections (subnuclear and apical vacuolization in epithelial cells) and ( C ) four weeks after a discontinuation of the three months lasting dalarelin treatment, 200×; ( D–F ): VG staining, 100×; Collagen fibers are stained purple; ( D ) control; ( E ) two months of dalarelin treatment (signs of fibrosis), ( F ) two weeks after a discontinuation of the three months lasting dalarelin treatment; ( G–I ): HE staining; ( G, H ) After one and three months of cetrorelix administration (infiltration of granulocytes, apoptotic bodies), respectively; (I) two weeks after the cetrorelix treatment discontinuation; Magnification: ( G, I ) 100×, ( H ) 200×.

Article Snippet: Dalarelin acetate (BAPEX, Ryga) – a gift from prof. F. Ryszka (Biochefa; Sosnowiec, Poland) – and cetrorelix acetate (ChemPep, Inc., USA) were used in the experiment.

Techniques: Staining, Control

Effects of dalarelin and cetrorelix on morphological appearance of rat liver (HE staining). ( A–C ) rats treated with dalarelin for one (ID, focal necrosis) and three months (IIID, macrovesicular steatosis) and two weeks after the treatment discontinuation (IIID+2, increased number of mononuclear cells), respectively; ( D–F ) rats treated with cetrorelix for three months (IIIC, basophilic hepatocytes) and two (IIIC+2, signs of congestion, degenerating hepatocytes) and four weeks (IIIC+4) after the discontinuation, respectively. 1 st and 3 rd – zone 1 and 3 of liver acini, respectively. Magnification: ( A,C–F ) 100×; ( B ) 200×.

Journal: Medical Science Monitor : International Medical Journal of Experimental and Clinical Research

Article Title: Morphological and enzymatic changes caused by a long-term treatment of female rats with a low dose of gonadoliberin agonist and antagonist

doi: 10.12659/MSM.883264

Figure Lengend Snippet: Effects of dalarelin and cetrorelix on morphological appearance of rat liver (HE staining). ( A–C ) rats treated with dalarelin for one (ID, focal necrosis) and three months (IIID, macrovesicular steatosis) and two weeks after the treatment discontinuation (IIID+2, increased number of mononuclear cells), respectively; ( D–F ) rats treated with cetrorelix for three months (IIIC, basophilic hepatocytes) and two (IIIC+2, signs of congestion, degenerating hepatocytes) and four weeks (IIIC+4) after the discontinuation, respectively. 1 st and 3 rd – zone 1 and 3 of liver acini, respectively. Magnification: ( A,C–F ) 100×; ( B ) 200×.

Article Snippet: Dalarelin acetate (BAPEX, Ryga) – a gift from prof. F. Ryszka (Biochefa; Sosnowiec, Poland) – and cetrorelix acetate (ChemPep, Inc., USA) were used in the experiment.

Techniques: Staining

Identification of connective tissue fibers in the liver of rats administered dalarelin and cetrorelix and after the treatment discontinuation (VG staining). Portal space and surrounding cells are shown. Collagen fibers are stained purple, elastic fibers are stained black. ( A ) control; ( B ) two months of dalarelin treatment; ( C ) one week after a discontinuation of the three months lasting dalarelin treatment; ( D ) one month and ( E ) three months of cetrorelix treatment; ( F ) one week after the cetrorelix treatment discontinuation; Magnification: 100×.

Journal: Medical Science Monitor : International Medical Journal of Experimental and Clinical Research

Article Title: Morphological and enzymatic changes caused by a long-term treatment of female rats with a low dose of gonadoliberin agonist and antagonist

doi: 10.12659/MSM.883264

Figure Lengend Snippet: Identification of connective tissue fibers in the liver of rats administered dalarelin and cetrorelix and after the treatment discontinuation (VG staining). Portal space and surrounding cells are shown. Collagen fibers are stained purple, elastic fibers are stained black. ( A ) control; ( B ) two months of dalarelin treatment; ( C ) one week after a discontinuation of the three months lasting dalarelin treatment; ( D ) one month and ( E ) three months of cetrorelix treatment; ( F ) one week after the cetrorelix treatment discontinuation; Magnification: 100×.

Article Snippet: Dalarelin acetate (BAPEX, Ryga) – a gift from prof. F. Ryszka (Biochefa; Sosnowiec, Poland) – and cetrorelix acetate (ChemPep, Inc., USA) were used in the experiment.

Techniques: Staining, Control

Densitometric evaluation of histochemical reactions for the activities of succinate dehydrogenase (SDH), NADH-tetrazolium reductase (NADH-TR), lactate dehydrogenase (LDH), Mg 2+ -dependent ATPase (Mg 2+ -ATPase) and acidic phosphatase (AcP) in rat adenohypophysis, during one (I), two (II) and three month (III) lasting administration of placebo (K), dalarelin (D) and cetrorelix (C), as well as after one (III+1), two (III+2) and four (III+4) weeks after discontinuation of a treatment. All values are expressed as units of optical density.

Journal: Medical Science Monitor : International Medical Journal of Experimental and Clinical Research

Article Title: Morphological and enzymatic changes caused by a long-term treatment of female rats with a low dose of gonadoliberin agonist and antagonist

doi: 10.12659/MSM.883264

Figure Lengend Snippet: Densitometric evaluation of histochemical reactions for the activities of succinate dehydrogenase (SDH), NADH-tetrazolium reductase (NADH-TR), lactate dehydrogenase (LDH), Mg 2+ -dependent ATPase (Mg 2+ -ATPase) and acidic phosphatase (AcP) in rat adenohypophysis, during one (I), two (II) and three month (III) lasting administration of placebo (K), dalarelin (D) and cetrorelix (C), as well as after one (III+1), two (III+2) and four (III+4) weeks after discontinuation of a treatment. All values are expressed as units of optical density.

Article Snippet: Dalarelin acetate (BAPEX, Ryga) – a gift from prof. F. Ryszka (Biochefa; Sosnowiec, Poland) – and cetrorelix acetate (ChemPep, Inc., USA) were used in the experiment.

Techniques:

Histochemical reactions for the activity of succinate dehydrogenase (SDH), NADH-tetrazolium reductase (NADH-TR), lactate dehydrogenase (LDH), Mg 2+ -dependent ATPase (Mg 2+ -ATPase) and acidic phosphatase (AcP) in the rat adenohypophysis in control groups (IIK, IIIK), and dalarelin (IIID) or cetrorelix (IC, IIC, IIIC) treated rats. Magnification: IIC − 200×; others − 100×.

Journal: Medical Science Monitor : International Medical Journal of Experimental and Clinical Research

Article Title: Morphological and enzymatic changes caused by a long-term treatment of female rats with a low dose of gonadoliberin agonist and antagonist

doi: 10.12659/MSM.883264

Figure Lengend Snippet: Histochemical reactions for the activity of succinate dehydrogenase (SDH), NADH-tetrazolium reductase (NADH-TR), lactate dehydrogenase (LDH), Mg 2+ -dependent ATPase (Mg 2+ -ATPase) and acidic phosphatase (AcP) in the rat adenohypophysis in control groups (IIK, IIIK), and dalarelin (IIID) or cetrorelix (IC, IIC, IIIC) treated rats. Magnification: IIC − 200×; others − 100×.

Article Snippet: Dalarelin acetate (BAPEX, Ryga) – a gift from prof. F. Ryszka (Biochefa; Sosnowiec, Poland) – and cetrorelix acetate (ChemPep, Inc., USA) were used in the experiment.

Techniques: Activity Assay, Control

Densitometric evaluation of histochemical reactions for the activities of succinate dehydrogenase (SDH), NADH-tetrazolium reductase (NADH-TR), lactate dehydrogenase (LDH), glucose-6-phosphatase (G6Pase), Mg 2+ -dependent ATPase (Mg 2+ -ATPase) and acidic phosphatase (AcP) in 1 st and 3 rd zone of rat liver acini during one (I), two (II) and three month (III) lasting administration of placebo (K), dalarelin (D) and cetrorelix (C), as well as after one (III+1), two (III+2) and four (III+4) weeks after discontinuation of a treatment. All values are expressed as units of optical density.

Journal: Medical Science Monitor : International Medical Journal of Experimental and Clinical Research

Article Title: Morphological and enzymatic changes caused by a long-term treatment of female rats with a low dose of gonadoliberin agonist and antagonist

doi: 10.12659/MSM.883264

Figure Lengend Snippet: Densitometric evaluation of histochemical reactions for the activities of succinate dehydrogenase (SDH), NADH-tetrazolium reductase (NADH-TR), lactate dehydrogenase (LDH), glucose-6-phosphatase (G6Pase), Mg 2+ -dependent ATPase (Mg 2+ -ATPase) and acidic phosphatase (AcP) in 1 st and 3 rd zone of rat liver acini during one (I), two (II) and three month (III) lasting administration of placebo (K), dalarelin (D) and cetrorelix (C), as well as after one (III+1), two (III+2) and four (III+4) weeks after discontinuation of a treatment. All values are expressed as units of optical density.

Article Snippet: Dalarelin acetate (BAPEX, Ryga) – a gift from prof. F. Ryszka (Biochefa; Sosnowiec, Poland) – and cetrorelix acetate (ChemPep, Inc., USA) were used in the experiment.

Techniques:

Histochemical reactions for the activity of succinate dehydrogenase (SDH), NADH-tetrazolium reductase (NADH-TR), lactate dehydrogenase (LDH), glucose-6-phosphatase (G6Pase), Mg 2+ -dependent ATPase (Mg 2+ -ATPase) and acidic phosphatase (AcP) in the liver of rats from control group (IIIK), and rats treated three months with dalarelin (IIID) or cetrorelix (IIIC). Magnification: AcP − 200×; others − 100×.

Journal: Medical Science Monitor : International Medical Journal of Experimental and Clinical Research

Article Title: Morphological and enzymatic changes caused by a long-term treatment of female rats with a low dose of gonadoliberin agonist and antagonist

doi: 10.12659/MSM.883264

Figure Lengend Snippet: Histochemical reactions for the activity of succinate dehydrogenase (SDH), NADH-tetrazolium reductase (NADH-TR), lactate dehydrogenase (LDH), glucose-6-phosphatase (G6Pase), Mg 2+ -dependent ATPase (Mg 2+ -ATPase) and acidic phosphatase (AcP) in the liver of rats from control group (IIIK), and rats treated three months with dalarelin (IIID) or cetrorelix (IIIC). Magnification: AcP − 200×; others − 100×.

Article Snippet: Dalarelin acetate (BAPEX, Ryga) – a gift from prof. F. Ryszka (Biochefa; Sosnowiec, Poland) – and cetrorelix acetate (ChemPep, Inc., USA) were used in the experiment.

Techniques: Activity Assay, Control

Biochemical parameters of the blood of female rats during one (I), two (II) and three month (III) lasting administration of placebo, dalarelin and cetrorelix, as well as after one (III+1), two (III+2) and four (III+4) weeks after discontinuation of a treatment.

Journal: Medical Science Monitor : International Medical Journal of Experimental and Clinical Research

Article Title: Morphological and enzymatic changes caused by a long-term treatment of female rats with a low dose of gonadoliberin agonist and antagonist

doi: 10.12659/MSM.883264

Figure Lengend Snippet: Biochemical parameters of the blood of female rats during one (I), two (II) and three month (III) lasting administration of placebo, dalarelin and cetrorelix, as well as after one (III+1), two (III+2) and four (III+4) weeks after discontinuation of a treatment.

Article Snippet: Dalarelin acetate (BAPEX, Ryga) – a gift from prof. F. Ryszka (Biochefa; Sosnowiec, Poland) – and cetrorelix acetate (ChemPep, Inc., USA) were used in the experiment.

Techniques: Control

The activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and creatine kinase (CK) in the blood of female rats during one (I), two (II) and three month (III) lasting administration of placebo, dalarelin and cetrorelix, as well as after one (III+1), two (III+2) and four (III+4) weeks after discontinuation of a treatment.

Journal: Medical Science Monitor : International Medical Journal of Experimental and Clinical Research

Article Title: Morphological and enzymatic changes caused by a long-term treatment of female rats with a low dose of gonadoliberin agonist and antagonist

doi: 10.12659/MSM.883264

Figure Lengend Snippet: The activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and creatine kinase (CK) in the blood of female rats during one (I), two (II) and three month (III) lasting administration of placebo, dalarelin and cetrorelix, as well as after one (III+1), two (III+2) and four (III+4) weeks after discontinuation of a treatment.

Article Snippet: Dalarelin acetate (BAPEX, Ryga) – a gift from prof. F. Ryszka (Biochefa; Sosnowiec, Poland) – and cetrorelix acetate (ChemPep, Inc., USA) were used in the experiment.

Techniques: Control

Schematic depiction of typical ovarian Stimulation protocols. In Group 1, GnRH Antagonist (Cetrorelix acetate 0.25 mg daily injections) was started from day 1 of stimulation concurrently with r-FSH ( A ); In Group 2, r-FSH was started on cycle day 1or 2 and flexible GnRH antagonist administration initiated from day 5 or 6 of stimulation ( B ).

Journal: Journal of Clinical Medicine

Article Title: Optimizing Ovarian Stimulation for IVF in PCOS Patients: A Novel Day 1 GnRH Antagonist Protocol

doi: 10.3390/jcm14165901

Figure Lengend Snippet: Schematic depiction of typical ovarian Stimulation protocols. In Group 1, GnRH Antagonist (Cetrorelix acetate 0.25 mg daily injections) was started from day 1 of stimulation concurrently with r-FSH ( A ); In Group 2, r-FSH was started on cycle day 1or 2 and flexible GnRH antagonist administration initiated from day 5 or 6 of stimulation ( B ).

Article Snippet: Patients who had been administered a GnRH antagonist in the form of 0.25 mg Cetrorelix acetate daily injections (Cetrolix, Intas Pharmaceuticals Ltd.) early from day 1 of stimulation were considered as Group 1 (Test cohort), and patients who had received 0.25 mg Cetrorelix acetate daily injections from day 5 or day 6 as per the standard flexible protocol were considered as Group 2 (Control cohort).

Techniques: